Journal of Lipid Research, Vol. 1, 159-163, January 1960
Copyright © 1960 by Lipid Research, Inc.

Lack of nicotinic acid effect on cholesterol metabolism of the rat

Charles H. Duncan and Maurice M. Best

Department of Medicine, University of Louisville School of Medicine, Louisville 2, Kentucky

The effect of the addition of 1 per cent nicotinic acid to the diet of the rat on serum, liver, and carcass cholesterol, and on the incorporation of acetate-1-C¹⁴ into cholesterol by the intact animal were studied. The effect of nicotinic acid on absorption of cholesterol-4-C¹⁴ and on the elimination of labeled cholesterol from serum and liver were also studied. No significant effect of nicotinic acid, fed for either 8 or 42 days, on the incorporation of acetate-1-C¹⁴ into serum and liver cholesterol was observed. When weight gain of the control animals was limited to that of the nicotinic-acid-fed rats by pair-feeding, nicotinic acid had no significant effect on serum or liver cholesterol concentrations, nor on total carcass cholesterol. Absorption of cholesterol-4-C¹⁴ and the disappearance of labeled cholesterol from serum and liver were not influenced by nicotinic acid administration by stomach tube.

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