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Journal of Lipid Research, Vol. 1, 164-166, January 1960
Copyright © 1960 by Lipid Research, Inc.

Effects of intravenous heparin on oxidation of fat

A. Michajlik and J. H. Bragdon

Section on Metabolism, National Heart Institute, National Institutes of Health, Bethesda 14, Maryland

The intravenous injection of heparin to carbohydrate-fed rats results in an elevation of plasma free fatty acid levels and in a lowering of the respiratory quotient from 1.0 to 0.9. The injection of heparin simultaneously with palmitic acid-C14-labeled chylomicrons results in an elevation of the specific radioactivity of the expired CO2. These observations suggest that heparin causes an obligatory oxidation of fat, presumably through the release of free fatty acid from triglyceride.

Submitted on September 22, 1959


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 ANGIOLOGYHome page
D. Berkowitz, A. Woldow, W. Likoff, and J. J. Spitzer
The Effects of Heparin On the Serum Triglyceride and Radioactive Fat Tolerance
Angiology, April 1, 1961; 12(4): 139 - 143.
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