Journal of Lipid Research, Vol. 1, 171-178, January 1960
Copyright © 1960 by Lipid Research, Inc.

Effect of cerebroside preparations on sterol excretion in the rat

K. K. Carroll

The Collip Medical Research Laboratory, University of Western Ontario, London, Ontario, Canada

The addition of cerebroside preparations to synthetic diets fed to rats caused an increased excretion of sterol in the feces as measured by the Liebermann-Burchard reaction. The mixed fatty acid esters obtained by hydrolyzing the cerebrosides had a similar but less marked effect. Both cerebrosides and fatty acid esters increased the concentration of Liebermann-Burchard-positive sterol in the feces. The amounts of sterol in the diet were insufficient to contribute significantly to the fecal sterol and no component of the cerebroside preparations other than fatty acids was found to affect sterol excretion. The activity displayed by the fatty acid fraction did not seem to be restricted to one particular fatty acid. Cholesterol was found to be the main chromogenic sterol in the feces during the first week that cerebrosides were fed. Possible mechanisms for this response to the feeding of cerebrosides are discussed.

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