J. Lipid Res.
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Journal of Lipid Research, Vol. 1, 203-207, April 1960
Copyright © 1960 by Lipid Research, Inc.

The structure of cerebrosides in Gaucher's disease

G. V. Marinetti , T. Ford , and Elmer Stotz

Department of Biochemistry, University of Rochester School of Medicine and Dentistry, Rochester 20, N. Y.

Crystalline cerebrosides were isolated from the spleen of a woman with Gaucher's disease. The cerebrosides accounted for 38 per cent of the total spleen lipids and 0.89 per cent of the fresh spleen. The sugar moiety of the cerebrosides was found to be glucose and its position of attachment was established to be on the primary hydroxyl group of sphingosine. The double bond in the sphingosine moiety had the trans configuration. The fatty acids of the cerebroside were determined by gas chromatography and paper chromatography and found to be mainly lignoceric, behenic, and palmitic acid. Small amounts of arachidic and stearic acids were also present.

Submitted on October 24, 1959


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