Journal of Lipid Research, Vol. 1, 221-228, April 1960
Copyright © 1960 by Lipid Research, Inc.

Studies on the distribution of tocopherol in human serum lipoproteins

Eugene C. McCormick , David G. Cornwell , and J. B. Brown

Department of Physiological Chemistry, The Ohio State University, Columbus 10, Ohio

The tocopherol content of human serum proteins, isolated by density gradient and homogeneous density procedures, was determined by the Emmerie-Engel and phosphomolybdic acid methods. Serum tocopherol is found primarily in the lipoproteins. The low density lipoproteins, principally the S_f 3-9 lipoproteins, contain a major part of the total serum tocopherol, while high density lipoproteins contain the remainder. Serum tocopherol increases after oral administration and remains elevated for 24 hours. The increment in serum tocopherol from newly absorbed tocopherol is found first in the chylomicron and S_f 10-400 lipoprotein fractions. A tocopherol peak occurs in these fractions 4 hours after oral administration. This peak is followed by an increment in the tocopherol content of the S_f 3-9 and high density lipoprotein fractions which reaches a maximum plateau in from 8 to 10 hours and remains elevated from 14 to 16 hours. The distribution of newly absorbed tocopherol is discussed in relation to lipid absorption and transport of other lipids by the serum lipoproteins.

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