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Journal of Lipid Research, Vol. 1, 301-304, July 1960
Copyright © 1960 by Lipid Research, Inc.

Immunochemical studies of organ and tumor lipids: VIII. comparison of human tumor and ox spleen cytosides

Maurice M. Rapport , Liselotte Graf , and Nicholas F. Alonzo

Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, New York 61, N. Y.; and Division of Experimental Pathology, Sloan-Kettering Institute for Cancer Research, New York 21, N. Y.

Preparations of cytolipin H, a human tissue lipid hapten containing fatty acid, sphingosine, glucose, and galactose in equimolar proportions (cytoside), have been compared with preparations of similar composition isolated from ox spleen. The iodine number and the specific rotation of preparations derived from human tumor are significantly larger than those from ox spleen. Results of other chemical analyses (based on the carbohydrate and sphingosine portions of the molecule) as well as immunochemical reactions are indistinguishable for both.

Submitted on March 2, 1960


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