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Journal of Lipid Research, Vol. 1, 321-325, July 1960
Copyright © 1960 by Lipid Research, Inc.

NH2-terminal amino acids of the serum lipoproteins of normal and hypercholesterolemic rabbits

B. Shore and V. Shore

Department of Physiology, Washington University School of Medicine, St. Louis 10, Missouri

Aspartic acid is the major and glutamic acid and serine are minor NH2-terminal amino acids of the lipoproteins of rabbit serum. No NH2-terminal amino acids other than these are found after prolonged cholesterol feeding. The hyperlipoproteinemia accompanying the feeding is not characterized by any significant changes in the NH2-terminal amino acid composition of the density (d) < 1.007, 1.007 to 1.019, or 1.065 to 1.20 lipoproteins. However, in the d = 1.019 to 1.065 lipoproteins, the percentages of NH2-terminal glutamic acid and aspartic acid seem to increase and decrease, respectively, during feeding.

Submitted on January 20, 1960


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