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Journal of Lipid Research, Vol. 1, 326-331, July 1960
Copyright © 1960 by Lipid Research, Inc.

Uptake and metabolism of triglycerides by the rat liver

Y. Stein and B. Shapiro

Department of Biochemistry, Hebrew University-Hadassah Medical School, and Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel

Triglycerides were prepared with C14 in the glycerol moiety and tritium in the fatty acid part as well as with over-all tritium labeling. Tracer amounts of these triglycerides were incorporated into blood plasma lipoproteins and the solutions were injected intravenously into rats. Large amounts of the radioactive material were recovered in the liver 15 minutes after the injection and the triglycerides were located predominantly in the liver mitochondria and microsomes, with relatively little in the fat droplets. Five minutes after the injection of doubly labeled triglycerides, the triglycerides recovered in the liver had practically the same H3- to C14- ratio as the injected material, indicating that intravenous lipolysis is not necessary for the uptake of neutral fat by the liver. After longer intervals the H3- to C14-ratio in the triglycerides increased rapidly, indicating intrahepatic lipolysis with the loss of free glycerol and re-esterification of the fatty acid with endogenous unlabeled glycerol precursors. Part of the tritiated fatty acids was also recovered in the phospholipid fraction, while very little of the C14-glycerol was used in phospholipid synthesis.

Submitted on January 21, 1960


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