Journal of Lipid Research, Vol. 1, 339-342, July 1960
Copyright © 1960 by Lipid Research, Inc.

The influence of epinephrine and fasting on adipose tissue content and release of free fatty acids in obese-hyperglycemic and lean mice

Norman B. Marshall and Frank L. Engel

Department of Nutrition, The Upjohn Company, Kalamazoo, Michigan; and the Departments of Medicine and Physiology, Division of Endocrinology, Duke University Medical Center, Durham, North Carolina

Epididymal-fat-pad adipose tissue obtained from obese-hyperglycemic mice exhibited an impairment in its ability to mobilize free fatty acids (FFA) when incubated with epinephrine and in response to a 16-hour fast. Unexpectedly, FFA production by adipose tissue of fed obese mice was significantly greater than that observed in adipose tissue obtained from lean littermates. It is suggested that the impaired mobilization of FFA may be implicated in the etiology of this type of obesity.

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