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Journal of Lipid Research, Vol. 1, 466-468, October 1960
Copyright © 1960 by Lipid Research, Inc.

Effect of adrenergic blocking agents on the release of free fatty acids from rat adipose tissue

Michael C. Schotz and Irvine H. Page

Research Division of the Cleveland Clinic Foundation and the Frank E. Bunts Educational Institute, Cleveland 6, Ohio

Epididymal adipose tissue from epinephrine-treated rats release more fatty acids into the medium during in vitro incubation than do tissues from untreated rats. The effect of epinephrine was abolished when an adrenergic blocking agent was administered to the animals before epinephrine was injected. Experiments in vitro showed that increased release of free fatty acids from adipose tissue due to addition of ACTH, epinephrine, and norepinephrine was inhibited by addition of an adrenergic blocking agent to the medium. The results suggest that mobilization of fatty acids from fat depots is at least partly under the control of vasomotor nerves.

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