J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Journal of Lipid Research, Vol. 1, 469-473, October 1960
Copyright © 1960 by Lipid Research, Inc.

Plasma cholesterol lowering action of bile acid binding polymers in experimental animals

David M. Tennent , Henry Siegel , Mary E. Zanetti , Gunther W. Kuron , Walther H. Ott , and Frank J. Wolf

Merck Institute for Therapeutic Research and the Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey

Feeding of bile acid binding polymeric organic bases inhibited cholesterol rise and aortic plaque formation in cholesterol-fed cockerels, lowered plasma cholesterol concentrations in normocholesterolemic cockerels and dogs, and increased fecal bile acid and sterol output in a dog. In experiments lasting as long as one year these substances have not produced visible toxic effects. They are thought to act by binding the bile acids in the intestinal tract.

Submitted on February 29, 1960


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