HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baker, N. Search for Related Content PubMed PubMed Citation Articles by Baker, N. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 10, 1-24, January 1969
Copyright © 1969 by Lipid Research, Inc.

The use of computers to study rates of lipid metabolism

Nome Baker

Radioisotope Research, Veterans Administration Center, Los Angeles, California 90073, and Department of Biological Chemistry, University of California at Los Angeles School of Medicine, Los Angeles, California 90024

Many complex problems of lipid metabolism are especially suited for multicompartmental analysis with computers. Examples are presented. The use of a model as a means of communicating one's working hypothesis and the model as it relates to experimental design are discussed. A number of principles relating to experimental design and to the interpretation and presentation of data are illustrated by 12 studies selected from the literature. These include evaluations of turnover and transport rates of liver and plasma triglycerides, triglyceride synthesis, phospholipid synthesis, and lipid oxidation to CO₂.

A discussion of computer-oriented vs. noncomputer-oriented techniques is included. Some of the practical problems involved in computer analysis are also considered. Among these are the choice of computer, computer applications, stepwise vs. multicompartmental analysis, validity of single-injection type experiments, avoidance of multicompartmental analysis, nonsteady state systems, and nomenclature.

Supplementary key words models • multicompartmental analysis • free fatty acids • triglycerides • phospholipids • carbon dioxide • oxidation • turnover rates • transport • irreversible disposal

Submitted on June 3, 1968

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Liberati, A. Ronchi, P. Lievens, S. Ottolenghi, and R. Mantovani NF-Y Organizes the gamma -Globin CCAAT Boxes Region J. Biol. Chem., July 3, 1998; 273(27): 16880 - 16889. [Abstract] [Full Text] [PDF]