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Journal of Lipid Research, Vol. 10, 41-46, January 1969
Copyright © 1969 by Lipid Research, Inc.

Gas-liquid chromatography-mass spectrometry of synthetic ceramides

Bengt Samuelsson and Karin Samuelsson

Department of Medical Chemistry, Royal Veterinary College; Department of Neurology, Karolinska Sjukhuset; and Laboratory of Mass Spectrometry, Karolinska Institutet, Stockholm, Sweden

Two series of ceramides with either sphingosine (sphing-4-enine) or sphinganine as base and with one of the saturated fatty acids C₁₆, C₁₈, C₂₀, C₂₂, C₂₄, C₂₆, or oleic acid were analyzed as the 1,3-di-O-trimethylsilyl ether derivatives by gas chromatography-mass spectrometry. The fragments formed on electron impact can be divided into three main groups, namely "molecular weight fragments," "long-chain base fragments," and "fatty acid fragments." The m/e values of these fragments can be used to determine unequivocally the structures of the long-chain base and fatty acid of a ceramide derived from a sphingolipid.

Supplementary key words trimethylsilyl ethers • sphingosine • sphinganine

Submitted on June 18, 1968
Accepted on August 16, 1968

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