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Journal of Lipid Research, Vol. 10, 331-337, May 1969
Copyright © 1969 by Lipid Research, Inc.
Division of Physiological Chemistry, Chemical Center, University of Lund, Lund, Sweden
The fecal excretion of cholesterol-4-14C and ßbeta;-sitosterol-22,23-3H has been studied in normal human subjects after they had ingested a single meal containing the radioactive substances.
When 150 mg of ßbeta;-sitosterol, dispersed in the butter of a standard breakfast, was fed to 20 subjects the mean recovery of isotope in the feces was 90%. When plant sterols (70% ßbeta;-sitosterol, 30% campesterol) were fed together with cholesterol and used as an internal standard to correct for losses of cholesterol during intestinal transit and analytical procedures, excretion of dietary cholesterol was found to be 60-80%, irrespective of the amount fed over the range 150-1910 mg. If absorption of cholesterol is calculated from these figures, no saturation of the cholesterol absorption mechanism is indicated for the amounts of cholesterol fed in this investigation.
The reason for the differences between these findings and those previously reported by other procedures is not clear, but may be related to the acute administration of a single dose of cholesterol in this study.
Supplementary key words intestinal absorption • external and internal standards • ßbeta;-sitosterol • fecal excretion
Submitted on September 9, 1968
Accepted on January 20, 1969
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