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Journal of Lipid Research, Vol. 10, 351-355, July 1969
Copyright © 1969 by Lipid Research, Inc.

Intestinal absorption and lymphatic transport of cholesterol in the rat: influence of the fatty acid chain length of the carrier triglyceride

Christer SylvÉN and Bengt BorgstrÖM

Division of Physiological Chemistry, Chemical Center, University of Lund, Lund, Sweden

This paper deals with the effect of the fatty acid chain length of dietary triglyceride on the intestinal uptake and lymphatic transport of exogenous and endogenous cholesterol in the rat. This question seemed of interest as the chain length of the monoglyceride and fatty acids formed in the intestinal lumen from the triglyceride fed could be expected to affect the concentration of cholesterol in the micellar or isotropic phase of intestinal content.

Feeding rats medium- or short-chain triglycerides (C₁₂ to C₂) did not affect the lymphatic transport of endogenous cholesterol from the intestine compared to the fasting state.

The extent of lymphatic transport of cholesterol added to these fats increased proportionally with chain length (C₆-C₁₈) of the component fatty acids. The uptake of exogenous cholesterol into the intestinal wall was similarly related to the chain length of the carrier triglyceride, with the exception of triacetin, which gave a much higher intestinal uptake than lymphatic transport.

When cholesterol was fed in octadecane, negligible amounts only were transported to the thoracic duct lymph. This again indicates the importance of the polar split products of dietary fat for cholesterol absorption.

Supplementary key words triacetin • coconut oil • medium-chain triglycerides • triolein • octadecane

Submitted on September 3, 1968
Accepted on February 19, 1969

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