J. Lipid Res.
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Journal of Lipid Research, Vol. 10, 421-426, July 1969
Copyright © 1969 by Lipid Research, Inc.

Bacterial 7-dehydroxylation of cholic acid and allocholic acid

Victor Bokkenheuser , Takahiko Hoshita , and Erwin H. Mosbach

Department of Microbiology, St. Luke's Hospital Center, New York 10025; The Public Health Research Institute of the City of New York, Inc., New York 10016; and The Bureau of Laboratories, New York City Department of Health, New York 10016

An obligate anaerobic organism capable of dehydroxylating cholic acid to deoxycholic acid and allocholic acid to allodeoxycholic acid was isolated from feces of the rabbit. It was a member of the bacteroides group (Gram-variable, nonsporulating anaerobes). The growth of the organism was inhibited by neomycin, 10-20 µg/ml. The existence of this organism affords a satisfactory explanation for the development of gallstones in the cholestanol-fed rabbit and for their absence in rabbits simultaneously treated with neomycin.

Supplementary key words deoxycholic acid • allodeoxycholic acid • gallstone • rabbit • anaerobe • neomycin

Submitted on November 22, 1968
Accepted on March 3, 1969


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