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Journal of Lipid Research, Vol. 10, 521-527, September 1969
Copyright © 1969 by Lipid Research, Inc.

Metabolism of d- and l-glyceraldehyde in adipose tissue: a stereochemical probe for glycerokinase activity

Gabor Antony , Lawrence W. White , and Bernard R. Landau

Departments of Medicine and Biochemistry, Western Reserve University, Cleveland, Ohio 44106

Distributions of ¹⁴C have been determined in free glycerol, in glycerol from triglycerides, in glucose from glycogen, and in lactate after incubation of d-glyceraldehyde-3-¹⁴C and l-glyceraldehyde-3-¹⁴C with rat adipose tissue. The distributions are interpreted in terms of presently accepted possible reactions for the initial metabolism of glyceraldehyde.

Formation of glycerol-1-¹⁴C from d-glyceraldehyde-3-¹⁴C indicates that in adipose tissue glyceraldehyde is reduced to glycerol. Incorporation of ¹⁴C from d-glyceraldehyde-3-¹⁴C into carbon 3 of the glycerol of triglyceride indicates that d-glyceraldehyde is either phosphorylated or oxidized to d-glyceric acid, or both, in its initial metabolism. Incorporation of ¹⁴C from l-glyceraldehyde-3-¹⁴C into carbon 3 of glycerol indicates that l-glyceraldehyde is reduced to glycerol, which is phosphorylated and (or) converted to d-glyceric acid via l-glyceric acid. Some ¹⁴C from l-glyceraldehyde-3-¹⁴C is incorporated into carbon 1 of glycerol of triglycerides and carbon 4 of glycogen; the explanation for this incorporation is uncertain.

Supplementary key words phosphorylation • reduction • glycerol • triglycerides • lactate • glycogen

Submitted on April 25, 1968
Revised on February 13, 1969
Accepted on May 7, 1969

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