Journal of Lipid Research, Vol. 10, 642-645, November 1969
Copyright © 1969 by Lipid Research, Inc.
Tritioboration and synthesis of tritium-labeled polyunsaturated fatty acids
Demetrios S. Sgoutas , Holly Sanders , and Esther M. Yang
The Burnsides Research Laboratory, University of Illinois, Urbana, Illinois 61801
Methyl esters of polyunsaturated fatty acids labeled with tritium were prepared by partial stereoselective reduction of the corresponding acetylenic esters with tritiated disiamylborane, followed by protonolysis with tritiated acetic acid. The labeling was strictly specific, and the tritium atoms were located only at the carbon atoms forming the unsaturated bond(s).
Synthesis of some tritiated fatty acid methyl esters with methylene-interrupted trans-cis double bonds is also reported.
Supplementary key words disiamylborane • cis-enynoic acids • trans-enynoic acids • polyynoic acids • methyl esters
Submitted on April 2, 1969
Accepted on July 8, 1969
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