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Journal of Lipid Research, Vol. 10, 646-655, November 1969
Copyright © 1969 by Lipid Research, Inc.

Feedback regulation of bile acid biosynthesis in the rat

Sarah Shefer , Susan Hauser , Ihor Bekersky , and Erwin H. Mosbach

Department of Laboratory Diagnosis, Public Health Research Institute of the City of New York, Inc., and the Bureau of Laboratories, New York City Department of Health, New York 10016

The hepatic biosynthesis of bile salts in the rat has been shown to be controlled homeostatically by the quantity of bile salt returning to the liver via the portal circulation. The feedback mechanism was demonstrated in two kinds of experiments. In the first, rats with bile fistulas were infused intraduodenally with sodium taurocholate 12 hr after surgery. If the rate of infusion was greater than 10 mg per 100 g rat per hr, the increase in bile acid output normally observed in bile fistula rats was prevented. In the second type of experiment, the rats were infused with taurocholate 48-72 hr after biliary diversion, when bile acid output had reached a maximal value. Provided the rate of infusion exceeded 10 mg per 100 g rat per hr, bile acid secretion returned to the low levels observed in intact rats. Previous attempts to demonstrate the feedback control have been unsuccessful because too little bile salt was infused.

The taurocholate pool of the experimental animals was measured as approximately 15 mg per 100 g rat; it was calculated from this and the above results that this pool circulated 10-13 times daily.

Supplementary key words bile fistula rat • biliary diversion • in vivo bile acid biosynthesis • bile acid pool • regulation • inhibition • feedback mechanism • enterohepatic circulation • enterohepatic circulation rate

Submitted on April 2, 1969
Accepted on July 8, 1969


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