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Journal of Lipid Research, Vol. 10, 687-693, November 1969
Copyright © 1969 by Lipid Research, Inc.

Structure of plasma sphingadienine

O. Renkonen and E. L. Hirvisalo

Department of Biochemistry, University of Helsinki, and Wihuri Research Institute, Helsinki, Finland

The dienic long-chain base (sphingadienine) of human plasma sphingomyelins has been identified as d-erythro-1,3-dihydroxy-2-amino-4-trans-14-cis-octadecadiene. A similar sphingosine was also detected in plasma sphingomyelins of rat, rabbit, and cat. The key reaction in the structural studies was partial reduction of sphingadienine with hydrazine to cis-14-sphingenine and 4-sphingenine.

Supplementary key words catalytic hydrogenation • sphinganine • specific rotation • 3-deoxysphinganine formation • thin-layer chromatography • partial hydrazine reduction • cis-14-sphingenine • 4-sphingenine

Submitted on May 8, 1969
Accepted on July 14, 1969


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