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Journal of Lipid Research, Vol. 11, 102-110, March 1970
Copyright © 1970 by Lipid Research, Inc.
Department of Biochemistry, University of Oxford, Oxford, England
The clearing factor lipase (lipoprotein lipase) activities of homogenates of fresh tissue and of acetone-ether powders have been compared in hearts from fed and starved rats.
The activity of the enzyme measured in homogenates of acetone-ether powders is generally higher than that in homogenates of the fresh tissue. Activation is due to an effect of the acetone-ether treatment on enzyme which is associated with the tissue residue in fresh tissue homogenates. A similar activation occurs when the tissue residue is treated with deoxycholate.
When rats are fasted, a marked increase in the clearing factor lipase activity of the heart occurs. Peak activities are reached after 10-24 hr, and thereafter the activity falls slowly. This pattern of activity is observed in homogenates of fresh tissue and of acetone-ether powders. The activity of clearing factor lipase in diaphragm muscle also increases in rats starved for 8 or 24 hr.
The importance of the change in muscle clearing factor lipase activity on fasting in relation to triglyceride fatty acid utilization by this tissue is emphasized.
Supplementary key words triglyceride fatty acid utilization • skeletal muscle
Submitted on August 7, 1969
Revised on November 20, 1969
Accepted on December 5, 1969
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