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Journal of Lipid Research, Vol. 11, 322-330, July 1970
Copyright © 1970 by Lipid Research, Inc.
Molecular Disease Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
An analysis of the lipids in normal human liver is presented which is particularly designed to assist in the classification and study of lipid-storage diseases. Special emphasis has been given to a determination of the quantity and composition of the neutral glycolipid classes and predominant ganglioside (Gm3). The neutral glycolipid content of 0.19 (sd ± 0.11) µmoles per g wet tissue, represented 0.4% of the total lipid in liver. Ceramide dihexoside was the most abundant neutral glycolipid. The mean contents of cholesterol, glycerides, and total phospholipids were 3.9, 19.5, and 25.1 mg/g wet weight, respectively. The relative amounts of seven different phospholipid classes were also determined; these included cardiolipin (diphosphatidylglycerol), which constituted 3.9% of the liver phospholipids.
Supplementary key words cholesterol • triglyceride • phospholipid • neutral glycolipids • gangliosides • hematoside • cardiolipin • sphingomyelin
Submitted on December 29, 1969
Accepted on March 17, 1970
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