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Journal of Lipid Research, Vol. 11, 341-345, July 1970
Copyright © 1970 by Lipid Research, Inc.

Effect of cellulose in the diet on the recovery of dietary plant sterols from the feces

L. Denbesten , William E. Connor , Thomas H. Kent , and Don Lin

The Departments of Surgery, Internal Medicine, and Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52240

In one normal subject, J.S., fed several formula diets in a sterol balance study, only 25-58% of the ingested plant sterols were recovered from the stool. The dietary plant sterols were completely recovered from the stools of five other men. Plant sterol recovery was complete in all men when a diet of mixed general foods was consumed.

Since the chief differences in composition of the formula and the diet of mixed general foods were related to the different contents of cellulose and lactose, these components were added to the formula diet of J.S., and plant sterol balance studies were then carried out. The addition of fresh celery or pulverized cellulose to the formula diet partially corrected the usual fecal loss of plant sterols (80% being recovered). Lactose in the formula was only slightly corrective. However, the addition of both cellulose and lactose led to complete recovery of the ingested plant sterols in the feces.

Bacterial cultures of stools were incubated with added cholesterol-4-¹⁴C, and a linear relationship between losses of sterol during balance studies and in vitro incubations was observed; that is, a considerable loss of the labeled cholesterol from cultures after the formula diet, but not after the diet of mixed general foods. This in vitro loss was also corrected by the addition of cellulose and lactose to the formula diet.

The loss of the sterol nucleus in the intestinal tract may occur at times because of the lack of certain dietary constituents. It is hypothesized that the metabolism of intestinal tract bacteria is altered when certain constituents are not present in the diet, and that these bacteria may then degrade the sterol nucleus.

Supplementary key words cholesterol • ßbeta;-sitosterol • cholesterol balance • degradation • cholesteryl sulfate • formula diet

Submitted on January 8, 1970
Accepted on April 13, 1970

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