Journal of Lipid Research, Vol. 11, 362-366, July 1970
Copyright © 1970 by Lipid Research, Inc.
Effect of bile acid deconjugation on the fecal excretion of steroids
Thomas F. Kellogg , P. Leonard Knight , and Bernard S. Wostmann
Lobund Laboratory and Department of Microbiology, Biochemistry and Biophysics Program, University of Notre Dame, Notre Dame, Indiana 46556
The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which accelerated cholesterol catabolism in mice. When this species of bacteria was associated with germfree rats, the fecal bile acids were excreted as free bile acids (deconjugated), however the quantities of bile acids excreted were not increased compared with those of germfree rats. Conventional rats excrete twice as much bile acids (all deconjugated) as do the germfree and C. perfringens-associated rats. It is, therefore, unlikely that the microbiological deconjugation of bile acids is responsible for the increased fecal excretion of bile acids seen in conventional rats.
The C. perfringens-associated rats excreted identical kinds and quantities of fecal neutral sterols as did the germfree rats.
Supplementary key words dehydroxylation • sterol balance in rats • fecal sterols
Submitted on January 9, 1970
Accepted on April 20, 1970
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