Journal of Lipid Research, Vol. 11, 433-438, September 1970
Copyright © 1970 by Lipid Research, Inc.
Fatty acids of glycosphingolipids from pig blood fractions
Eric Coles and J. Lindsley Foote
Western Michigan University, Department of Chemistry, Kalamazoo, Michigan 49001
Four glycolipids have been isolated from three fractions of pig blood. The glycolipids were presumably cerebroside, diglycosyl ceramide, triglycosyl ceramide, and globoside. The blood fractions were erythrocytes and plasma high and low density lipoproteins. Fatty acid distributions were determined for each glycolipid as a means to assist in identifying relationships among the several glycolipids. Normal fatty acids predominated in all glycolipids except the globosides from erythrocytes in which the amount of hydroxy acids was slightly greater than the amount of normal acids. Hydroxy acids appeared to be present in all the glycolipids, but the concentration was very low in cerebrosides isolated from high density lipoproteins and erythrocytes, and in diglycosyl ceramide and globoside of the low density lipoproteins. In general, the average fatty acid chain length increased from cerebroside to globoside. This was most apparent in erythrocytes and also greater for normal acids than for hydroxy acids. Fatty acid distributions of erythrocyte glycolipids had sufficient variation to make a metabolic relationship by simple addition of a hexose appear doubtful. While the fatty acid distributions found in plasma lipoproteins were more similar, some means of acyl group selection is probably present for either the synthesis or degradation of these glycolipids.
Supplementary key words glycolipids • hydroxy fatty acids • erythrocytes • plasma lipoproteins
Submitted on October 30, 1969
Accepted on May 21, 1970
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