| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol. 11, 439-457, September 1970
Copyright © 1970 by Lipid Research, Inc.
Pulmonary Research Laboratory, Mt. Sinai Hospital of Cleveland, University Circle, Cleveland, Ohio 44106
A procedure is described for the isolation of a surface-active fraction from dog lung. This material meets the established criteria for pulmonary surfactant. The fraction was shown to contain lipid, protein, and carbohydrate. The predominant lipid present was dipalmitoyl phosphatidylcholine. Surface chemistry studies indicated the surface properties of the fraction could not be explained solely from a consideration of the properties of dipalmitoyl phosphatidylcholine. Electron microscopic studies demonstrated the presence of intact osmiophilic bodies as well as other myelin forms in the surface-active fraction. It is speculated that, in situ, the alveolar lining layer is similar to a structured gel.
Supplementary key words pulmonary surfactant • dipalmitoyl phosphatidylcholine • osmiophilic bodies
Submitted on March 24, 1970
Accepted on May 27, 1970
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Tashiro, K. Ohta, X. Cui, K. Nishizuka, K. Yamamoto, T. Konzaki, T. Kobayashi, and Y. Suzuki Effects of various forms of surfactant protein C on tidal volume in ventilated immature newborn rabbits J Appl Physiol, April 1, 2003; 94(4): 1519 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Hills An alternative view of the role(s) of surfactant and the alveolar model J Appl Physiol, November 1, 1999; 87(5): 1567 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Grossmann, K. Tashiro, T. Kobayashi, Y. Suzuki, Y. Matsumoto, Y. Waseda, T. Akino, T. Curstedt, and B. Robertson Experimental neonatal respiratory failure induced by lysophosphatidylcholine: effect of surfactant treatment J Appl Physiol, February 1, 1999; 86(2): 633 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. HERMANS and A. BERNARD Lung Epithelium-specific Proteins . Characteristics and Potential Applications as Markers Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 646 - 678. [Full Text]
|
|
|
|
|
|
M. Oulton, E. Edwards, and K. Handa Convertase activity in alveolar surfactant and lamellar bodies in fetal, newborn, and adult rabbits J Appl Physiol, January 1, 1999; 86(1): 71 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kobayashi, K. Tashiro, K. Yamamoto, S. Nitta, S. Ohmura, and Y. Suzuki Effects of surfactant proteins SP-B and SP-C on dynamic and static mechanics of immature lungs J Appl Physiol, December 1, 1997; 83(6): 1849 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Grossmann, Y. Suzuki, B. Robertson, T. Kobayashi, P. Berggren, W.-Z. Li, G.-W. Song, and B. Sun Pathophysiology of neonatal lung injury induced by monoclonal antibody to surfactant protein B J Appl Physiol, June 1, 1997; 82(6): 2003 - 2010. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
