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Journal of Lipid Research, Vol. 11, 480-485, September 1970
Copyright © 1970 by Lipid Research, Inc.

Biosynthesis of presqualene pyrophosphate by liver microsomes

H. C. Rilling

Department of Biochemistry, University of Utah College of Medicine, Salt Lake City, Utah 84112

Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is identical with presqualene pyrophosphate, a 30-carbon cyclopropane containing pyrophosphate ester that had previously been isolated from yeast. The squalene precursor was found to be tightly, but not covalently, bound to microsomes.

Supplementary key words squalene biosynthesis • farnesyl pyrophosphate

Submitted on November 3, 1969
Accepted on May 21, 1970

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