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Journal of Lipid Research, Vol. 11, 517-521, November 1970
Copyright © 1970 by Lipid Research, Inc.

Mobilization of fatty acids in genetically obese rats

George A. Bray , Stella Mothon , and Andrea S. Cohen

New England Medical Center Hospitals and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111

The mobilization of fatty acids has been studied in genetically obese rats of the Zucker strain and in control obese animals with bilateral destructive lesions in the hypothalamus. The body weight and size of adipose cells did not differ significantly between the genetically obese rats and the obese controls. Weight loss in control and genetically obese rats was identical during a 1 month fast. The release of glycerol and the rise in free fatty acids in adipose tissue incubated in vitro were similar in tissue from genetic and hypothalamic obese rats. Epinephrine, theophylline, and dibutyryl cyclic adenosine monophosphate all augmented lipolysis, and the effects were usually greater in the tissues from genetically obese rats.

Supplementary key words hypothalamic obesity • epinephrine • theophylline • dibutyryl cyclic AMP

Submitted on March 5, 1970
Accepted on July 13, 1970

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