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Journal of Lipid Research, Vol. 11, 522-527, November 1970
Copyright © 1970 by Lipid Research, Inc.

Effect of essential fatty acid deficiency on release of triglycerides by the perfused rat liver

Toshio Fukazawa ¹, O. S. Privett ¹, and Yoshiyata Takahashi ²

¹ The Hormel Institute, University of Minnesota, Austin, Minnesota 55912
² Third Department of Internal Medicine, University of Tokyo, Tokyo, Japan

Studies are reported on release of triglycerides during perfusion of livers of male Sprague-Dawley rats fed a fat-free diet or diets containing hydrogenated coconut oil or corn oil. Perfusions were carried out with Krebs-Ringer bicarbonate buffer containing albumin with and without infusion of oleate or linoleate.

Infusion with sodium oleate or linoleate caused an accumulation of triglycerides in the livers of the corn oil-fed animals and stimulated the release of triglycerides into the perfusing medium. In similar experiments with essential fatty acid-deficient animals, which were fed fat-free diets or diets containing hydrogenated coconut oil, there was no increase in secretion of triglycerides into the perfusate, and the amount of triglyceride which accumulated in the liver was greater than in the livers of the control (corn oil-fed) animals. Tracer experiments with oleate-1-¹⁴C or linoleate-1-¹⁴C also showed that with livers of essential fatty acid-deficient animals, secretion of triglyceride into the perfusate was not stimulated by infusion of fatty acids into the perfusing medium. It is concluded that impairment of the secretion of triglycerides is a factor in the accumulation of fat in the livers of essential fatty acid-deficient animals.

Supplementary key words fatty liver • liver triglycerides

Submitted on December 29, 1969
Accepted on July 17, 1970

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