J. Lipid Res. Acyl Labeled PIP's available August 1, 2008
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Journal of Lipid Research, Vol. 11, 551-557, November 1970
Copyright © 1970 by Lipid Research, Inc.

Determination of the optimal priming dose for achieving an isotopic steady state in a two-pool system: application to the study of cholesterol metabolism

D. B. Zilversmit and Richard A. Wentworth

Graduate School of Nutrition and Section of Biochemistry and Molecular Biology, Division of Biological Sciences and the Department of Physical Biology, Cornell University, Ithaca, New York 14850

The daily administration of labeled cholesterol to humans or animals leads to an isotopic steady state. The specific activity of plasma cholesterol in the isotopic steady state gives information about the fraction of plasma cholesterol derived from endogenous and exogenous sources. A method, based on a two-pool model, is presented which allows the estimation of an optimal priming dose of labeled cholesterol whereby the time to reach the isotopic steady state is reduced to a minimum. A graphic procedure is presented which allows the estimation of an optimal priming dose for two-compartment systems with widely differing characteristics.

Supplementary key words isotope kinetics

Submitted on May 19, 1970
Accepted on August 3, 1970


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