Journal of Lipid Research, Vol. 12, 31-35, January 1971
Copyright © 1971 by Lipid Research, Inc.

Properties of cholesteryl esters in pure and mixed monolayers

Chui N. Kwong , Richard E. Heikkila , and David G. Cornwell

Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio 43210

The surface properties of cholesteryl palmitate, stearate, linoleate, linolenate, arachidonate, and acetate were investigated. Long-chain esters were not surface-active and force-area (-A) isotherms were not obtained. Unsaturated cholesteryl esters were oxidized at the air-water interface and these oxidized lipids gave expanded -A isotherms. Cholesteryl acetate had an equilibrium spreading pressure of 14.0 dynes/cm and formed a stable monolayer indistinguishable from cholesterol below that surface pressure. Cholesteryl linoleate formed mixed monolayers with surface-active lipids, and the amount of cholesteryl linoleate in the monolayer depended both on its solubility in the other lipid and on the surface pressure. Even at moderate surface pressures cholesteryl linoleate was extruded from the monolayer into a bulk phase. Cholesteryl acetate exhibited the well-known condensing effect of cholesterol in mixed monolayers with egg lecithin.

Supplementary key words palmitate • stearate • linoleate • linolenate • arachidonate • acetate • surface area • equilibrium spreading pressure • mixed monolayer • condensing effect • stability • oxidation

Submitted on January 29, 1970
Accepted on October 1, 1970

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