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Journal of Lipid Research, Vol. 12, 76-83, January 1971
Copyright © 1971 by Lipid Research, Inc.

Mechanism of fatty liver development and hyperlipemia in rats treated with allylisopropylacetamide

Paul S. Roheim , Luis Biempica , Diane Edelstein , and Nechama S. Kosower

Departments of Physiology, Pathology, and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461

Treatment of rats with allylisopropylacetamide results in two related effects that occur sequentially. After one injection, serum FFA concentration increases and fatty liver develops without any decrease in lipoprotein synthesis. With repeated administration of the drug, fatty acid mobilization continues and acetate incorporation into lipids increases. However, fatty liver disappears with a concomitant increase in lipoprotein synthesis, resulting in hyperlipemia. It is postulated that accumulation of the liver lipid might be a regulating factor in the synthesis and transport of lipoproteins.

Supplementary key words serum triglyceride • serum free fatty acids • plasma lipoprotein synthesis • acetate incorporation • porphyria

Submitted on July 2, 1970
Accepted on October 13, 1970

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