J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Journal of Lipid Research, Vol. 12, 91-95, January 1971
Copyright © 1971 by Lipid Research, Inc.

Effect of cell size on epinephrine- and ACTH-induced fatty acid release from isolated fat cells

Oren Zinder and Benyamin Shapiro

Department of Biochemistry, The Hebrew University-Hadassah Medical School, Jerusalem, Israel

Free fatty acid release from fat cells, obtained from epididymal adipose tissue of rats of different sizes, was found to be dependent on the cell surface area, regardless of the age of the animals. The same result was found with cells of different sizes from the same animal. These results, when related to in vivo conditions, would indicate that for the same adipose tissue mass, activity would decrease with increasing cell size. On the other hand, the total activity of a given tissue would increase by increasing the size of its cells.

Supplementary key words lipolysis • cell surface area • plasma membrane

Submitted on June 29, 1970
Accepted on September 23, 1970


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