Journal of Lipid Research, Vol. 12, 132-138, March 1971
Copyright © 1971 by Lipid Research, Inc.
The synthesis of higher glycerides via the monoglyceride pathway in hamster adipose tissue
F. Michael Schultz and John M. Johnston
Department of Biochemistry, The University of Texas (Southwestern) Medical School, Dallas, Texas 75235
The monoglyceride pathway for the synthesis of triglycerides has been investigated employing subcellular fractions and whole cell preparations of white and brown adipose tissue. Conclusive evidence has been obtained for the monoglyceride pathway in these tissues by employing the 2-monoether analogue of 2-monoolein as the substrate. The monoglyceride and 
-glycerophosphate pathways were primarily found in the microsomal fraction. In these in vitro systems the activity of the monoglyceride pathway compared with the -glycerophosphate pathway was of the same order of magnitude in whole cell preparations and was approximately one-half the activity of the -glycerophosphate pathway when the microsomal fraction was employed.
Supplementary key words subcellular location • brown and white adipose tissue
Submitted on July 17, 1970
Accepted on October 23, 1970
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