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Journal of Lipid Research, Vol. 12, 149-154, March 1971
Copyright © 1971 by Lipid Research, Inc.

Effect of hemoglobin concentration on the oxidation of linoleic acid

Yasuharu Nakamura and Toshiro Nishida

The Burnsides Research Laboratory, University of Illinois, Urbana, Illinois 61801

The inhibitory effect of high concentrations of hemoglobin on the oxidation of linoleic acid was related to the ability of hemoglobin to associate with the fatty acid. Ultracentrifugation of the mixture of hemoglobin and potassium linoleate revealed that approximately 880 moles of linoleic acid could associate with 1 mole of hemoglobin. High concentrations of hemoglobin apparently reduced the amount of free linoleic acid accessible to the heme group, thus preventing the oxidation of the fatty acid. With low hemoglobin concentrations, at which the oxidation began immediately after the addition of the catalyst, the amount of free linoleic acid was considerably greater than that of bound linoleic acid.

Supplementary key words heme • induction period

Submitted on August 25, 1969
Revised on October 19, 1970
Accepted on November 11, 1970

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