Journal of Lipid Research, Vol. 12, 155-159, March 1971
Copyright © 1971 by Lipid Research, Inc.
Surface pressure-surface area characteristics of a series of autoxidation products of cholesterol
Aida M. Kamel , Alvin Felmeister , and Norman D. Weiner
College of Pharmacy, Rutgers University, Newark, New Jersey 07104; and College of Pharmaceutical Sciences, Columbia University, New York 10023
The 
-A characteristics of seven known oxidation products of cholesterol were determined. In all cases, the oxidation products yielded films which were more expanded than the film of cholesterol. Shifts in the position of the functional polar groups or the double bond within the sterol molecule results in marked changes in the -A curves. Furthermore, replacement of the 3-hydroxy group by a keto group results in a significant decrease in the collapse pressure of the films. Mixed films of each of the oxidation products with dipalmitoyl glycerylphosphorylcholine, egg lecithin, and cholesterol showed marked condensation effects. However, the data suggest that if air oxidation of cholesterol did occur at a biological membrane containing cholesterol and phospholipids, the permeability characteristics and other properties of the membrane might not be altered significantly.
Supplementary key words lecithin • oxidized cholesterol • monolayers
Submitted on July 30, 1970
Accepted on November 11, 1970
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