Journal of Lipid Research, Vol. 12, 294-305, May 1971
Copyright © 1971 by Lipid Research, Inc.
Effect of free fatty acid mobilization on the electrophoretic mobility of 
-lipoproteins in the dog
Manuel J. Lipson and Shapur Naimi
New England Medical Center Hospitals and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111
Dogs were given infusions of norepinephrine and subsequent additional infusions of propranolol and nicotinic acid over a 4-hr period. Under different physiological conditions, 
-lipoproteins of three different electrophoretic mobilities were identified by means of paper electrophoresis; they were designated -lipoproteins X, Y, and Z. During norepinephrine infusion, -lipoprotein Y fell from 45% (of all lipoproteins) to 14%. There was a reciprocal rise in -lipoprotein Z. On the other hand, -lipoprotein X was not significantly changed. There was evidence that -lipoprotein Y was progressively transformed into -lipoprotein Z by increasing plasma FFA concentrations. The percentages of both -lipoproteins Y and Z returned to original values after the dogs were given either nicotinic acid or propranolol. The alterations in the -lipoprotein peaks Y and Z were rapid, being noted within 5 min of change in plasma FFA concentration. However, there appeared to be a threshold of plasma FFA concentration of 1200 µEq/liter, below which no changes in -lipoproteins were noted. It was concluded that -lipoprotein Y is rapidly, progressively, but reversibly transformed into -lipoprotein Z by binding to plasma FFA above a threshold level of 1200 µEq/liter. However, -lipoprotein X does not appear to be involved in the binding of plasma FFA.
Supplementary key words propranolol • nicotinic acid • norepinephrine • catecholamines • ßbeta;-lipoproteins • atherosclerosis • lipoproteins • thrombogenesis
Submitted on July 21, 1970
Accepted on January 5, 1971
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