J. Lipid Res.
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Journal of Lipid Research, Vol. 12, 473-481, July 1971
Copyright © 1971 by Lipid Research, Inc.

Studies of brain myelin in the "quaking mouse"

H. Singh , N. Spritz , and B. Geyer

Department of Medicine, New York University School of Medicine, and Lipid Metabolism Laboratory, Veterans Administration Hospital, New York 10010

Myelin was isolated from the brains of "quaking" and littermate control animals and its composition was determined. The brains of quaking animals contained approximately one-fourth as much myelin as the control animals. There were qualitative as well as quantitative differences between the myelin from the two groups. By continuous cesium chloride gradient flotation it was shown that the myelin from the quaking animals consisted solely of a band corresponding to the heavier and smaller of the two bands found in normal controls. Cholesterol and glycolipids were lower and phospholipids (mainly phosphatidylcholine) and protein were higher in quaking animals than in controls. Also, phosphatidal-ethanolamine was decreased, and several consistent differences in the fatty acids (both unsubstituted and hydroxy) and aldehydes of the component lipids were found. In general there were smaller amounts of monounsaturated fatty acids in quaking animals. We suggest from these findings that myelin in the quaking mouse has certain compositional similarities with juvenile myelin, but it may be an abnormal type of myelin.

Supplementary key words phospholipids • glycolipids • cholesterol • fatty acids • protein • hydroxy acids • gas-liquid chromatography • thin-layer chromatography

Submitted on July 17, 1970
Accepted on March 9, 1971


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