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Journal of Lipid Research, Vol. 12, 596-603, September 1971
Copyright © 1971 by Lipid Research, Inc.

Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat

T. S. Shiff , P. S. Roheim , and H. A. Eder

Departments of Medicine and Physiology, Albert Einstein College of Medicine, Bronx, New York 10461

The effect of feeding a semipurified diet high in sucrose on serum lipid and lipoprotein concentrations was studied. In rats fed this diet the serum triglyceride concentration doubled, and liver triglyceride concentration increased by 30%. A fivefold increase in VLDL protein concentration and a small but significant increase of HDL protein concentration was also observed. In these rats there was increased incorporation of labeled amino acids into the proteins of plasma VLDL and HDL.

Fatty livers developed in the animals receiving 4-aminopyrazolopyrimidine, and levels of serum triglyceride and cholesterol fell markedly. The concentration of all lipoprotein classes decreased, with VLDL showing the most marked effect. Incorporation of labeled amino acids into lipoproteins and other plasma proteins was depressed.

Supplementary key words fatty liver • serum triglycerides • serum cholesterol • adenine • hyperlipemia • synthesis of serum lipoproteins

Submitted on May 4, 1970
Accepted on June 2, 1971


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