HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rothblat, G. H. Articles by Burns, C. H. Search for Related Content PubMed PubMed Citation Articles by Rothblat, G. H. Articles by Burns, C. H. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 12, 653-661, November 1971
Copyright © 1971 by Lipid Research, Inc.

Comparison of the metabolism of cholesterol, cholestanol, and ßbeta;-sitosterol in L-cell mouse fibroblasts

George H. Rothblat and Christina H. Burns

The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104

The following data have been obtained from comparative studies on the metabolism of cholesterol, cholestanol, and ßbeta;-sitosterol by L-cell mouse fibroblasts. (1) When the sterols are added to the growth medium under similar conditions, cellular incorporation of cholesterol > cholestanol > ßbeta;-sitosterol; (2) only limited cellular esterification of these compounds occurs; (3) no metabolic products arising from the sterols could be detected; (4) influx of all sterols is dependent upon the concentration; and (5) exogenous cholesterol reduces mevalonate incorporation into cellular sterol to a lesser extent than acetate or glucose. The metabolism of these sterols is discussed in relation to their ability to influence de novo sterol biosynthesis.

Supplementary key words desmosterol • sterol synthesis • feedback inhibition

Submitted on January 28, 1971
Accepted on June 10, 1971

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?