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Journal of Lipid Research, Vol. 12, 680-687, November 1971
Copyright © 1971 by Lipid Research, Inc.

Bile acid sulfates. II. Formation, metabolism, and excretion of lithocholic acid sulfates in the rat

Robert H. Palmer

Department of Medicine, The University of Chicago, Pritzker School of Medicine, and Argonne Cancer Research Hospital, Chicago, Illinois 60637

Sulfate esterification has been shown previously to be a prominent feature of lithocholate metabolism in man. These studies were undertaken to ascertain whether this metabolic pathway is also present in rats, and to investigate the physiological significance of bile acid sulfate formation. Lithocholic acid-24-¹⁴C was administered to bile fistula rats, and sulfated metabolites were identified in bile by chromatographic and appropriate degradative procedures. They constituted only a small fraction (2-9%) of the total metabolites but a more significant fraction (about 20%) of the secreted monohydroxy bile acids, most of the lithocholate having been hydroxylated by the rat liver. When sulfated glycolithocholate was administered orally, it was absorbed from the intestine without loss of the sulfate, presumably by active transport, and secreted intact into the bile. In comparison with non-sulfated lithocholate, an unusually large fraction (24%) of the sulfated bile acid was excreted in the urine, and fecal excretion took place more rapidly. Both the amino acid and sulfate moieties were extensively removed prior to excretion in the feces. Hydroxylation of bile acid sulfates or sulfation of polyhydroxylated bile acids did not occur to any great extent, if at all.

Supplementary key words rat bile • glycolithocholic acid sulfate • absorption • renal excretion of bile acids • fecal excretion of bile acids

Submitted on December 1, 1970
Accepted on June 18, 1971

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