Journal of Lipid Research, Vol. 12, 740-746, November 1971
Copyright © 1971 by Lipid Research, Inc.
Formation of 1-O-2'-hydroxyalkyl glycerophosphatides from 1,2-heptadecanediol in myelinating brain
Toshio Muramatsu and Harald H. O. Schmid
University of Minnesota, The Hormel Institute, Austin, Minnesota 55912
1,2-Heptadecanediol-2-14C was administered intracerebrally to 18-day-old rats, and its incorporation, after 8 hr, into the individual aliphatic moieties of the ethanolamine glycerophosphatides was determined.
Much of the radioactivity was found in a lipid fraction identified as 1-O-2'-hydroxyheptadecyl glycerol. Evidence is presented that a major portion of the precursor was incorporated into 1-O-2'-hydroxyheptadecyl-2-acyl ethanolamine phosphatides.
Some of the diol administered was degraded to palmitic acid. The palmitic acid-1-14C derived from 1,2-heptadecanediol-2-14C apparently served as precursor for stearic and oleic acids, which were found as acyl groups, and for the biosynthesis of the corresponding O-alkyl and O-alk-1-enyl glycerols.
The data presented prove that biological dehydration of 1-O-2'-hydroxyalkyl glycerophosphatides to the corresponding plasmalogens does not occur in myelinating brain.
Supplementary key words ethanolamine phosphatides • alkyl acyl glycerols • alk-1-enyl acyl glycerols • diacyl glycerols • intracerebral injection • 1,2-heptadecanediol-2-14C
Submitted on March 29, 1971
Accepted on July 6, 1971
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