Journal of Lipid Research, Vol. 12, 766-767, November 1971
Copyright © 1971 by Lipid Research, Inc.

A note on the stability of conjugated diene absorption of rat liver microsomal lipids after carbon tetrachloride poisoning

S. Srinivasan and Richard O. Recknagel

Department of Physiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106

Liver microsomal lipid peroxidation has been observed in fatal human CCl₄ poisoning, in rats with fatty livers induced by CCl₄ or by yellow phosphorus, and in mice poisoned with 1,1,2,2-tetrachloroethane. These observations suggest the possibility that other instances of toxic liver injury may involve lipid peroxidation. Cases of acute, fatal, toxic liver injury (e.g., from halothane anesthesia) are not likely to occur at or near laboratories equipped to determine whether any lipid peroxidation might have taken place. The data presented indicate that rat livers may be stored frozen for at least 7 days with no demonstrable diminution in CCl₄-induced conjugated diene absorption of liver microsomal lipids.

Supplementary key words liver injury • lipid peroxidation

Submitted on May 21, 1971
Accepted on July 8, 1971

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