J. Lipid Res.
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Journal of Lipid Research, Vol. 13, 17-22, January 1972
Copyright © 1972 by Lipid Research, Inc.

Effect of adrenalectomy on the diurnal variation of hepatic cholesterogenesis in the rat

Peter E. Hickman , Brian J. Horton , and John R. Sabine

Department of Animal Physiology, Waite Agricultural Research Institute, University of Adelaide, Adelaide, S.A., Australia

The diurnal variation in cholesterol synthesis exhibited by rat liver has been examined in fed, fasted, and adrenalectomized animals.

Fasting for 3 days caused a lowering of the rate of synthesis but did not abolish the diurnal rhythm. Adrenalectomy abolished the diurnal variation, and caused synthesis to remain at a uniformly high level. We suggest that corticosterone may play an essential role in the daily rhythm of cholesterogenesis.

Supplementary key words fasting • corticosterone • thyroid hormones

Submitted on April 19, 1971
Accepted on July 20, 1971


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