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Journal of Lipid Research, Vol. 13, 2-11, January 1972
Copyright © 1972 by Lipid Research, Inc.

Cellularity of adipose depots in six strains of genetically obese mice

P. R. Johnson and Jules Hirsch

The Rockefeller University, New York 10021

Adipocyte cell size and number of three adipose depots, gonadal, subcutaneous, and retroperitoneal, were determined in several strains (aAy, aAiy, dbdb, obob, and NZO) of adult genetically obese mice, male and female, and in male gold thioglucose-treated mice. Epididymal pad cellularity was determined during development in yellow and viable yellow obese mice and their lean littermates, as well as in the NCS/R mouse. Cell number in the mouse epididymal pad in both lean and genetically obese animals is determined early in development, i.e., before weaning. Cell enlargement is the consistent and usually dominant morphological explanation for adipose depot enlargement in genetic and in gold thioglucose-induced mouse obesity. In some instances, hyperplasia accompanied the hypertrophy, occurring most often in the subcutaneous depot. Cell number in the subcutaneous pad of the obese-hyperglycemic female is four times that of the lean control and represents the most extreme case of hyperplasia observed. In fact, hyperplasia was consistently seen in the obob mouse. A classification for genetic obesity based primarily upon the cellularity characteristics of the adipose depots is proposed.

Supplementary key words adipocyte • cell size • cell number • gold thioglucose obesity

Submitted on April 12, 1971
Accepted on July 14, 1971


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