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Journal of Lipid Research, Vol. 13, 27-31, January 1972
Copyright © 1972 by Lipid Research, Inc.

Fatty liver induction: inverse relationship between hepatic neutral lipid accumulation and dietary polyunsaturated fatty acids in orotic acid-fed rats

L. A. Witting

L. B. Mendel Research Laboratory, Elgin State Hospital, Elgin, Illinois 60120, and Department of Biological Chemistry, University of Illinois College of Medicine, Chicago, Illinois 60612

The levels of hepatic neutral lipids in the orotic acid-fed rat were inversely related to the dietary levels of polyunsaturated fatty acids, as in the choline-deficient rat. Hepatic microsomal protein and phospholipid and total hepatic phospholipid were increased in orotic acid-induced fatty livers. The increase in phospholipid was largely restricted to the phosphatidylethanolamines.

Supplementary key words choline • polyunsaturated fatty acids • linoleate • linolenate • phosphatidylethanolamine

Submitted on April 6, 1971
Accepted on July 27, 1971


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