Journal of Lipid Research, Vol. 13, 201-206, March 1972
Copyright © 1972 by Lipid Research, Inc.

Metabolism of lipid in the human fatty streak lesion

Aram V. Chobanian and Francisco Manzur

Department of Medicine, Boston University School of Medicine, and Boston City Hospital, Boston, Massachusetts 02118

The composition and synthesis of lipid have been examined in normal intima and adjacent fatty streak lesions of human arterial segments which were incubated with [2-¹⁴C]acetate. The incorporation of acetate into lipid was greater in fatty streaks than in normal intima. There was increased acetate incorporation into all major lipid groups in the fatty streak, with the greatest relative increase in the cholesteryl ester fraction. The major radiolabeled arterial fatty acid was a long-chain polyenoic fatty acid with chromatographic properties of a C22:4 acid. The content of fatty acid in the fatty streaks differed from that in normal intima, with substantial increases in the C18:1 acid and decreases in C16:0, C18:0, and C18:2 acids of the fatty streak. It is concluded that lipid synthesis is increased in the human fatty streak lesion and that the local metabolism of lipid contributes to its accumulation within the fatty streak.

Supplementary key words arterial lipid metabolism • human arterial metabolism • atherosclerosis

Submitted on February 9, 1971
Revised on June 22, 1971
Accepted on October 21, 1971

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