Journal of Lipid Research, Vol. 13, 253-255, March 1972
Copyright © 1972 by Lipid Research, Inc.

Autoxidation of cholesterol in aqueous dispersions and in monomolecular films

Norman D. Weiner , Papavadee Noomnont , and Alvin Felmeister

College of Pharmaceutical Sciences, Columbia University, New York 10023; and College of Pharmacy, Rutgers University, New Brunswick, New Jersey 08903

The autoxidative formation of 7-ketocholesterol and diols from aqueous cholesterol dispersions and from cholesterol monomolecular films has been studied as a function of time. The rate of oxidation of cholesterol is much faster at the surface than in the bulk. Whereas more than one-half of the cholesterol is oxidized at the surface within 8 hr at room temperature, no noticeable reaction was observed for the oxidation of cholesterol from aqueous dispersions at room temperature during this time period. However, similar rates of oxidation were observed when the dispersions were maintained at 85°C.

Supplementary key words 7-ketocholesterol • 7-hydroxy-cholesterol

Submitted on August 19, 1971
Accepted on November 11, 1971

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