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Journal of Lipid Research, Vol. 13, 263-267, March 1972
Copyright © 1972 by Lipid Research, Inc.

Intracellular sites of lipid synthesis and the biogenesis of mitochondria

Edward A. Dennis and Eugene P. Kennedy

Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115

Experimental data are presented on the intracellular localization in rat liver of three enzymes which are involved in the biosynthesis of phosphatidylethanolamine and diphosphatidylglycerol. These enzymes are phosphatidylserine decarboxylase, CDP-diglyceride-l--glycerophosphate phosphatidyl transferase, and phosphatidylethanolamine-l-serine phosphatidyl transferase. It was found that the first two enzymes are primarily mitochondrial while the latter enzyme is primarily microsomal. The intracellular sites for the biosynthesis of phosphatidylcholine, phosphatidylethanolamine, and diphosphatidylglycerol are discussed, and the implications of their sites of biosynthesis on the assembly processes involved in the biogenesis of mitochondria are considered.

Supplementary key words assembly • CDP-diglyceride-l--glycerophosphate phosphatidyl transferase • diphosphatidylglycerol • exchange enzyme • phosphatidylcholine • phosphatidylethanolamine • phosphatidylethanolamine-l-serine phosphatidyl transferase • phosphatidylserine decarboxylase

Submitted on August 20, 1971
Accepted on November 5, 1971

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