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Journal of Lipid Research, Vol. 13, 293-310, May 1972
Copyright © 1972 by Lipid Research, Inc.

Biosynthesis and metabolic degradation of sphingolipids not containing sialic acid

Pierre Morell and Peter Braun

Saul R. Korey Department of Neurology, and the Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461; and Department of Biochemistry, The School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Interest in sphingolipid metabolism has increased rapidly during the past decade, and many of the steps involved in the biosynthesis and metabolic degradation of sphingolipids are now known. In this review these studies are critically examined. Emphasis has been placed on the in vitro studies with cell-free systems, since these represent the groundwork for further purification and characterization of the enzyme systems involved. Experimental problems specific to this field of study, and the manner in which these may affect interpretation of experimental results, are discussed.

Supplementary key words long-chain bases • glycosphingolipids • inborn errors of sphingolipid metabolism • ceramide • sphingomyelin • cerebroside • sulfatide • globoside • blood groups

Submitted on June 23, 1971
Accepted on January 10, 1972

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